{"id":2467,"date":"2023-06-28T09:36:03","date_gmt":"2023-06-28T07:36:03","guid":{"rendered":"https:\/\/blogs.sun.ac.za\/dttc\/?page_id=2467"},"modified":"2024-01-18T11:30:54","modified_gmt":"2024-01-18T09:30:54","slug":"umoya","status":"publish","type":"page","link":"https:\/\/blogs.sun.ac.za\/dttc\/umoya\/","title":{"rendered":"Umoya"},"content":{"rendered":"
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Full study name: INTRA-THORACIC TBIN CHILDREN: MOVING TOWARDS BETTER DIAGNOSIS AND IMPROVED LUNG HEALTH<\/p>\n

Acronym: UMOYA (breathe)<\/p>\n

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Overview of study; include sub-studies; maybe say overview of platform<\/p>\n

Umoya is a unique ongoing prospective observational cohort of children presenting with symptoms of presumptive PTB. All children are systematically investigated for M. tuberculosis and other respiratory pathogens. Several diagnostic samples are collected at enrolment and during the first 6 months of follow-up. Long-term follow-up until 4 years after enrolment allows us to characterize the long-term effects of PTB on lung health in young children in the context of other common pathogens. Umoya provides a unique opportunity to investigate diagnostic tests\/ biomarkers and lung health in children with presumptive PTB. Umoya started recruitment November 2017 and currently has 563 children enrolled.<\/p>\n

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The clinical team comprises of two clinicians, 4 Research Nurses, 4 research counsellors, 2 drivers and social scientist.\u00a0 We have support staff from categories of research management, finance, laboratory and data. Support staff reside at the Headquarters of the Desmond Tutu TB Centre, Stellenbosch University Medical Campus and clinical visits take place at the Ikhamva research unit based at the Stellenbosch University Medical Campus.<\/p>\n

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Umoya initially started as a TB diagnostic study but over the past 5 years has developed into lung health research platform which is also a separate research pillar within the Desmond Tutu TB Centre\u00a0 https:\/\/blogs.sun.ac.za\/dttc\/core-research-competencies\/<\/a><\/p>\n

The project is focused on collecting high quality data related to TB diagnostics, respiratory pathogens and (post TB) lung health.<\/p>\n

The evidence produced from this project will improve the outcome of paediatric TB by earlier TB diagnosis, understanding markers of TB treatment response and gaining knowledge on alternative pathogens, and their joint impact with M. tuberculosis, on lung function and lung health in children, it will allow for the implementation of preventative and tailored therapeutic strategies in children. This could include tailored anti-tuberculosis treatment approaches, targeted vaccination for influenza or respiratory syncytial virus, and immune-modulating antibiotics.<\/p>\n

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Diagram below depicts the 2 main aims of the study, namely; To test and validation new TB diagnostic tools and to investigate the long-term impact of TB and other viruses on child and lung health. Our well characterized biorepository of diagnostic samples include site of disease samples like saliva, nasopharyngeal aspirates, and other samples including urine, stool, serum and paxgene.<\/p>\n

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Children on long term follow-up<\/p>\n<\/div>\n<\/div><\/div>

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Grants awards:<\/strong><\/p>\n

In march 2021, Dr Marieke van der Zalm was awarded three international grants collectively valued over R44 million to study various aspects of tuberculosis (TB) and lung health in children. Two of the grants are from the National Institutes of Health (NIH) in the United States and the other one is from the European & Developing Countries Clinical Trials Partnership (EDCTP). Each of the grants are for a period of five years.<\/p>\n

https:\/\/www.facebook.com\/profile\/100064379693869\/search\/?q=marieke%20van%20der%20zalm<\/a><\/p>\n

Dr Samkelisiwe Nyamathe was awarded the prestigious position of being one of the 200 Mail and Guardian Young South Africans.\u00a0 This is an annual supplement celebrating exceptional young leaders making a positive impact in over 15 fields including arts, civil society, health, technology and sport. The event recognises young South Africans aged from 18 to 35 who are committed to creating a sustainable future.<\/p>\n

https:\/\/mg.co.za\/200YoungSouth...\/2023\/samkelisiwe-nyamathe\/<\/a><\/p>\n

Recent Conference presentations:<\/strong><\/p>\n

Stellenbosch University 67th<\/sup> Annual Academic Day we had two oral presentations \u00a0and one poster presentation based on the data from this study.<\/p>\n

Michaille Anthony a PhD student presented an oral and poster, \u00a0\u201c Domains and items to standardise holistic health-related quality of life assessment for children 0-5 years old with respiratory illnesses including pulmonary tuberculosis\u201d and \u201cHealth-related quality of life measures for children with respiratory illnesses: review and evidence synthesis\u201d.<\/p>\n

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Levern Africa a Research Counsellor on the study presented on \u201c Acceptability and Feasibility of Sample collection in young children presenting with presumptive TB in Cape Town, South Africa\u201d.<\/p>\n

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Recent Publications:<\/strong><\/p>\n

BMC Pulm Med.<\/a>\u00a02023; 23: 97.<\/p>\n

Published online 2023 Mar 22.\u00a0doi:\u00a010.1186\/s12890-023-02329-3<\/a><\/p>\n

PMCID:\u00a0PMC10032249<\/p>\n

PMID:\u00a036949477<\/a><\/p>\n

UMOYA: a prospective longitudinal cohort study to evaluate novel diagnostic tools and to assess long-term impact on lung health in South African children with presumptive pulmonary TB\u2014a study protocol<\/p>\n

Isabelle Dewandel<\/a>,1<\/sup>\u00a0Margaret van Niekerk<\/a>,1<\/sup>\u00a0Elisabetta Ghimenton-Walters<\/a>,1,2<\/sup>\u00a0Megan Palmer<\/a>,1<\/sup>\u00a0Michaile G. Anthony<\/a>,1<\/sup>\u00a0Carla McKenzie<\/a>,1<\/sup>\u00a0Rolanda Croucamp<\/a>,1<\/sup>\u00a0Galit Alter<\/a>,3,4<\/sup>\u00a0Anne-Marie Demers<\/a>,1,5,6<\/sup>\u00a0Gert van Zyl<\/a>,7,8<\/sup>\u00a0Mathilda Claassen<\/a>,7<\/sup>\u00a0Pierre Goussard<\/a>,9<\/sup>\u00a0Ruan Swanepoel<\/a>,10<\/sup>\u00a0Graeme Hoddinott<\/a>,1<\/sup>\u00a0Corne Bosch<\/a>,1<\/sup>\u00a0Rory Dunbar<\/a>,1<\/sup>\u00a0Brian Allwood<\/a>,11<\/sup>\u00a0Eric D. McCollum<\/a>,1,12<\/sup>\u00a0H. Simon Schaaf<\/a>,1<\/sup>\u00a0Anneke C. Hesseling<\/a>,1<\/sup>\u00a0and\u00a0Marieke M. van der Zalm<\/a>1<\/sup><\/p>\n

Staff achievements<\/strong><\/p>\n

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Completed Studies:<\/p>\n\n\n\n\n\n
Team member<\/strong><\/td>\nDegree\/Diploma\/short course<\/strong><\/td>\nInstitution<\/strong><\/td>\n<\/tr>\n
Ingrid Courtney<\/td>\nMaster\u2019s in Clinical Epidemiology<\/td>\nStellenbosch University<\/td>\n<\/tr>\n
Levern Africa<\/td>\nProject Management short course<\/td>\nStellenbosch University Business school<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ongoing studies:<\/p>\n\n\n\n\n\n\n
Team member<\/strong><\/td>\nDegree\/Diploma\/short course<\/strong><\/td>\nInstitution<\/strong><\/td>\n<\/tr>\n
Asikhangile Mtshabe<\/td>\nDegree: Bachelor of Commerce in Supply Chain Management<\/td>\nUNISA<\/td>\n<\/tr>\n
John Wolmarans<\/td>\nDegree: Bachelor of Commerce in Supply Chain Management<\/td>\nUNISA<\/td>\n<\/tr>\n
Asanda Mfazwe<\/td>\nOccupational Certificate: Cccupational Health and Safety Practitioner<\/td>\nOxbridge Academy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Special event \u2013 Bookdash\u00a0 https:\/\/bookdash.org\/what-we-do\/<\/a>
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We partnered with Bookdash since 2022 to bring books to children! Bookdash is an organisation who believes that every child should own a hundred books by the age of five-years. Evidence has shown that owning books are a key factor in a child\u2019s cognitive and socio-emotional development. To make a significant impact to the early learning opportunities for pre-school children in South Africa and globally. Our observation study has access to a large group of under-served children, in addition we see the children often for follow up over a period of 4 years, this has been key to our partnership. See below some pictures of the children receiving the books. \u00a0This partnership is on-going!<\/p>\n

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To learn more:<\/p>\n

Contact us: Principle Investigator mariekevdzalm@sun.ac.za<\/a>; Project manager mbunting@sun.ac.za<\/a><\/p>\n

To learn more about DTTC: [main website link]<\/p>\n

To learn more about TB: WHO website; Provincial links for TB services<\/p>\n

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Full study name: INTRA-THORACIC TBIN CHILDREN: MOVING TOWARDS BETTER DIAGNOSIS AND IMPROVED LUNG HEALTH Acronym: UMOYA (breathe) \u00a0   Overview of study; include sub-studies; maybe say overview of platform Umoya is a unique ongoing prospective observational cohort of children presenting with symptoms of presumptive PTB. All children are systematically investigated for M. tuberculosis and other […]<\/p>\n","protected":false},"author":10471,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-2467","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/2467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/users\/10471"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/comments?post=2467"}],"version-history":[{"count":13,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/2467\/revisions"}],"predecessor-version":[{"id":3746,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/2467\/revisions\/3746"}],"wp:attachment":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/media?parent=2467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}