{"id":3079,"date":"2023-09-26T22:38:55","date_gmt":"2023-09-26T20:38:55","guid":{"rendered":"https:\/\/blogs.sun.ac.za\/dttc\/?page_id=3079"},"modified":"2023-10-24T17:15:57","modified_gmt":"2023-10-24T15:15:57","slug":"benefit-kids-formulation-development","status":"publish","type":"page","link":"https:\/\/blogs.sun.ac.za\/dttc\/benefit-kids-formulation-development\/","title":{"rendered":"BENEFIT Kids | Formulation Development"},"content":{"rendered":"<div id=\"pl-3079\"  class=\"panel-layout\" ><div id=\"pg-3079-0\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-3079-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3079-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div class=\"panel-widget-style panel-widget-style-for-3079-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"text-align: left\"><b>Improving the availability of child-friendly formulations of 2nd-line TB drugs<\/b><\/p>\n<p style=\"text-align: left\"><span style=\"font-weight: 400\">Led by TB Alliance and in partnership with Stellenbosch University, the BENEFIT Kids project is working closely with generic manufacturers to accelerate progress and ensure the development of novel or optimised formulations of two key drugs, moxifloxacin and linezolid, to ensure that formulations are child-friendly and palatable. As part of this work, a study of the best tasting formulation blend of these drugs (ChilPref_ML) was successfully completed in healthy child volunteers in South Africa in 2022. The results, to be disseminated in 2023, have informed the taste selection of these new formulations.\u00a0 We will continue to build on this work and undertake more field work on optimal and practical delivery methods of TB medications to children.<\/span><\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3079-0-0-1\" class=\"so-panel widget widget_sow-headline\" data-index=\"1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-b9d01dbbd4de-3079\"\n\t\t\t\n\t\t><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tBENEFIT Kids: The ChilPref ML Study\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n<\/div><\/div><div id=\"panel-3079-0-0-2\" class=\"so-panel widget widget_media_video\" data-index=\"2\" ><div style=\"width:100%;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-3079-1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/youtube\" src=\"https:\/\/www.youtube.com\/watch?v=odMY_DTY6M0&#038;_=1\" \/><a href=\"https:\/\/www.youtube.com\/watch?v=odMY_DTY6M0\">https:\/\/www.youtube.com\/watch?v=odMY_DTY6M0<\/a><\/video><\/div><\/div><div id=\"panel-3079-0-0-3\" class=\"so-panel widget widget_sow-headline\" data-index=\"3\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-headline so-widget-sow-headline-default-b9d01dbbd4de-3079\"\n\t\t\t\n\t\t><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tRepresentative procedure for preparation of compounded BDQ syrup suspension from tablets\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"decoration\">\n\t\t\t\t\t\t<div class=\"decoration-inside\"><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n<\/div><\/div><div id=\"panel-3079-0-0-4\" class=\"so-panel widget widget_media_video\" data-index=\"4\" ><div style=\"width:100%;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-3079-2\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/vimeo\" src=\"https:\/\/vimeo.com\/788818062?loop=0&#038;_=2\" \/><a href=\"https:\/\/vimeo.com\/788818062?loop=0\">https:\/\/vimeo.com\/788818062?loop=0<\/a><\/video><\/div><\/div><div id=\"panel-3079-0-0-5\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"5\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><i><span style=\"font-weight: 400\">This video (courtesy TB Alliance) shows a representative procedure for preparation of compounded BDQ syrup suspension. This approach can make pills easier for patients to take.<\/span><\/i><\/p>\n<p><strong>Downloadable Guides:<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/iris.who.int\/bitstream\/handle\/10665\/370099\/9789240074309-eng.pdf?isAllowed=y&amp;sequence=1\"><span style=\"font-weight: 400\">DELAMANID: Use of delamanid in children and adolescents with multidrug- and rifampicin-resistant tuberculosis - Information note<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/iris.who.int\/bitstream\/handle\/10665\/370100\/9789240074286-eng.pdf?isAllowed=y&amp;sequence=1\"><span style=\"font-weight: 400\">BEDAQUILINE - Use of bedaquiline in children and adolescents with multidrug- and rifampicin-resistant tuberculosis - Information note<\/span><\/a><\/li>\n<\/ol>\n<p><strong>Publications:<\/strong><\/p>\n<ol>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000012\/art00001\"><span style=\"font-weight: 400\">Paediatric formulations for the treatment of drug resistant TB: closing the gaps<\/span><\/a><span style=\"font-weight: 400\">.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2022\/00000026\/00000012\/art00006\"><span style=\"font-weight: 400\">Stable sugar and sugar-free suspensions of pretomanid<\/span><\/a><span style=\"font-weight: 400\">.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000001\/art00005\"><span style=\"font-weight: 400\">Sugar and sugar-free liquid formulations of delamanid for patients with rifampicin-resistant TB.<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000002\/art00006\"><span style=\"font-weight: 400\">Extemporaneously compounded liquid formulations of clofazimine.<\/span><\/a><span style=\"font-weight: 400\">\u00a0<\/span><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2023\/00000027\/00000003\/art00005\"><span style=\"font-weight: 400\">Stable, compounded bedaquiline suspensions to support practical implementation of pediatric dosing in the field.<\/span><\/a><\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-3079-1\"  class=\"panel-grid panel-no-style\" ><div id=\"pgc-3079-1-0\"  class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\" ><\/div><div id=\"pgc-3079-1-1\"  class=\"panel-grid-cell panel-grid-cell-empty\" ><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Improving the availability of child-friendly formulations of 2nd-line TB drugs Led by TB Alliance and in partnership with Stellenbosch University, the BENEFIT Kids project is working closely with generic manufacturers to accelerate progress and ensure the development of novel or optimised formulations of two key drugs, moxifloxacin and linezolid, to ensure that formulations are child-friendly [&hellip;]<\/p>\n","protected":false},"author":12487,"featured_media":3474,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3079","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/3079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/users\/12487"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/comments?post=3079"}],"version-history":[{"count":15,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/3079\/revisions"}],"predecessor-version":[{"id":3525,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/pages\/3079\/revisions\/3525"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/media\/3474"}],"wp:attachment":[{"href":"https:\/\/blogs.sun.ac.za\/dttc\/wp-json\/wp\/v2\/media?parent=3079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}