DTTC Publications January – December 2019

DTTC Publications January 2019 – December 2019

Manuscripts

1.  Stangl AL, Lilleston P, Mathema H, Pliakas T, Krishnaratne S, Sievwright K, Bell-Mandla N, Vermaak R, Mainga T, Steinhaus M, Donnell D, Schaap A, Bock P, Ayles H, Hayes R, Hoddinott G, Bond V, Hargreaves JR; HPTN 071 (PopART) Study Team. Development of parallel measures to assess HIV stigma and discrimination among people living with HIV, community members and health workers in the HPTN 071 (PopART) trial in Zambia and South Africa. J Int AIDS Soc. 2019 Dec;22 (12):e25421. doi: 10.1002/jia2.25421. PMID: 31840400.

2.  Allwood B, van der Zalm M, Makanda G, Mortimer K, on behalf of the Steering Committee of the 1st International Post-Tuberculosis Symposium*. The long shadow post-tuberculosis: “When we started TB treatment, no-one told us that it would never leave us.” Lancet Infectious diseases. Lancet Infect Dis. 2019 Nov;19 (11):1170-1171. PMID: 31657778.  *Andre F.S. Amaral, Uzochukwu Egere, Denise Evans, Diane Gray, Graeme Hoddinott, OlenaIvanova, Rupert Jones, Florian M. Marx, Jamilah Meghji, Stellah Mpagama, Sanne van Kampen, Andrea Rachow, Ingrid Schoeman, Cari Stek, Dalene von Delft, Naomi Walker, and Robert Wallis.

3.  Basu Roy R, Whittaker E, Seddon JA, Kampmann B. Tuberculosis susceptibility and protection in children. Lancet Infect Dis 2019; 19: e96-e108. PMID: 30322790.

4. Bock P, Gunst C, Maschilla L, Holtman R, Grobbelaar N, Wademan D, Dunbar R, Fatti G, Kruger J, Ford N, Hoddinott G, Meehan SA. Retention in care and factors critical for effectively implementing antiretroviral adherence clubs in a rural district in South Africa. J Int AIDS Soc. 2019 Oct;22 (10):e25396. PubMed PMID: 31588668.

5.  Bock P, Nel K, Fatti G, Sloot R, Ford N, Voget J, Gunst C, Grobbelaar N, Louis F, Floyd S, Hayes R, Ayles H, Beyers N, Fidler S; HPTN 071 (PopART) Team. Renal dysfunction by baseline CD4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD4 count in the HIV Prevention Trials Network 071 [HPTN 071; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (PopART)] study in South Africa. HIV Med. 2019 Apr 8. PMID: 30963667.

6. Bond V, Ngwenya F, Viljoen L, Gumede D, Bwalya C, Mantantana J, Hoddinott G, Dodd PJ, Ayles H, Simwinga M, Wallman S, Seeley J. Value and limitations of Broad Brush Surveys used in   community-randomized trials in Southern Africa. Qualitative Health Research 2019; 29(5):700-718. PMID: 30556470. PMCID: PMC6533803.

7. Bond V, Nomsenge S, Mwamba M, Ziba D, Birch A, Mubekapi-Musadaidzwa C, Vanqa N, Viljoen L, Pliakas T, Ayles H, Hargreaves JR, Hoddinott G, Stangl A, Seeley J. “Being seen” at the clinic: Zambian and South African health worker reflections on the relationship between health facility spatial organisation and items and HIV stigma in 21 health facilities, the HPTN 071 (PopART) study. Health & Place. 2019; 55:87-99. PMID: 30528346. PMCID: PMC6358039.

8.  Chiang SS, Park S, White E, Cruz AT, Del Castillo H, Canales P, Friedman JF, Lecca L, Becerra MC, Seddon JA. Changes in weight-for-age z-score predict effectiveness of childhood tuberculosis therapy. J Ped Infect Dis 2019. PMID: 30715497.

9. Christian C, Burger, C., Claassens M, Bond V, and Burger R. 2019. Patient predictors of health-seeking behaviour for persons coughing for more than two weeks in high-burden tuberculosis communities: the case of the Western Cape, South Africa. BMC health services research, 19(1), p.160. PMID: 30866926

10. Crawford FW, Marx FM, Zelner J, Cohen T. Transmission modelling with regression adjustment for analyzing household-based studies of infectious disease: application to tuberculosis. Epidemiology. 2019 Nov 14. PMID:  31764276.

11.  Dheda K, Gumbo T, Maartens G, Dooley KE, Murray M, Furin J, Nardell EA, Warren RM. The Lancet Respiratory Medicine Commission: 2019. Update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis. Lancet Respir Med. 2019 Sep;7(9):820-826. PMID: 31486393.

12.  Dippenaar A, De Vos M, Marx FM, Adroub SA, van Helden PD, Pain A, Sampson SL, Warren RM. Whole genome sequencing provides additional insights into recurrent tuberculosis classified as endogenous reactivation by IS6110 DNA fingerprinting. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases. 2019:103948. Epub 2019/07/06. PubMed PMID: 31276801.

13.  du Preez K, Schaaf HS, Dunbar R, Swartz A, Naidoo P, Hesseling AC. A simple intervention can close the hospital-reporting gap for childhood tuberculosis in South Africa. Public Health Action [Accepted for publication]

14.  du Preez K, Seddon JA, Schaaf HS, Hesseling AC, Starke JR, Osman M, Lombard CJ, Solomons R. Global shortages of BCG vaccine and tuberculous meningitis in children. Lancet Glob Health. 2019 Jan;7(1):e28-e29. PMID: 30554756.

15.  Fatti G, Grimwood A, Nachega JB, Nelson JA, LaSorda K, van Zyl G, Grobbelaar N, Ayles H, Hayes R, Beyers N, Fidler S, Bock P, on behalf of the HPTN 071 (PopART) study team. Better Virological Outcomes amongst People Living with HIV Initiating Early Antiretroviral Treatment (CD4 counts >/= 500 cells/microL) in the HPTN 071 (PopART) Trial in South Africa. Clin Infect Dis. 2019 May; doi: 10.1093/cid/ciz214. PMID: 30877753.

16.  Fatti G, Shaikh N, Bock P, Nachega JB, Grimwood A. Letter to the Editor. South African National Adherence Guidelines: Need for Revision? Tropical Medicine International Health. First published. 5 Aug 2019. PMID:31381230.

17.  Fuente-Soro L, Iniesta C, López-Varela E, Cuna M, Anselmo R, Maixenchs M, Luis Bernado E, Augusto O, Gonzalez R, Munguambe K, Naniche D. Tipping the balance towards long-term retention in the HIV care cascade: a mixed methods study in Southern Mozambique. PLos one, August 2019. PMID: 31560689. PMCID: PMC6764678.

18.  Garcia-Prats AJ, Schaaf HS, Draper HR, Garcia-Cremades M, Winckler J, Wiesner L, Hesseling AC, Savic RM.  Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies. PLoS Med. 2019 Apr 30;16(4):e1002789. doi: 10.1371/journal.pmed.1002789. eCollection 2019 Apr.  PMID: 31039153.

19.  Garcia-Prats AJ, Purchase SE, Osman M, Draper HR, Schaaf HS, Wiesner L, Denti P, Hesseling AC.  Pharmacokinetics, Safety, and Dosing of Novel Pediatric Levofloxacin Dispersible Tablets in Children with Multidrug-Resistant Tuberculosis Exposure.  Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01865-18. doi: 10.1128/AAC.01865-18. Print 2019 Apr.  PMID: 30670421.

20.  Gröschel MI, Seddon JA, Prabowo SA, Migliori GB, Graham SM, van den Boom M, Dara M. European guidance on drug-resistant tuberculosis in children and adults. Lancet Child Adol Health 2019. Accepted for publication.

21.  Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, Dawson R, Mave V, Sanchez J, Mendoza A, Gonzales P, Kumarasamy N, Comins K, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo UG, Ferreira ACG, Mugah C, Harrington M, Jones L, Cox S, Smith B, Shah NS, Hesseling AC, Churchyard G; ACTG 5300/IMPAACT I2003 PHOENIX Feasibility study team. Feasibility of identifying household contacts of Rifampin- and multidrug-resistant tuberculosis cases at high risk of progression to tuberculosis disease. Clin Infect Dis. 2019 Mar 28. pii: ciz235. doi: 10.1093/cid/ciz235. [Epub ahead of print] PubMed PMID: 30942853.

22.  Gupta A, Hughes MD, Garcia-Prats AJ, McIntire K, Hesseling AC. 2019. Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons. PLoS Med 16(8): e1002882. PMID: 31415563.

23.  Gupta A, Montepiedra G, Aaron L, Theron GB, McCarthy K, Bradford S, Chipato T, Vhembo T, Stranix-Chibanda L, Onyango-Makumbi C, Masheto G, Violari A, Hesseling AC, Shin K, Zimmer B, Costello D, Sterling TR, Chakhtoura N, Jean-Philippe P, Weinberg A; IMPAACT P1078 TB APPRISE Study Team. Isoniazid preventive therapy in HIV-Infected pregnant and postpartum women. New England Journal of Medicine. 2019; 381:1333-1346. PMID: 31577875.

24.  Hayes RJ, Donnell D, Floyd S, Mandla N,  Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A,  Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Lynda Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Sista ND, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, and Fidler S for the HPTN 071 (PopART) Study Team. 2019. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART); July 18, 2019, N Engl J Med 2019; 381:207-218, DOI: 0.1056/NEJMoa1814556. PMID: 31314965.

25.  Hughes J, Reuter A, Chabalala B, Isaakidis P, Cox H, Mohr E. Adverse events among people on Delamanid for rifampicin-resistant tuberculosis in a high HIV prevalence setting. The International Journal of Tuberculosis and Lung Disease, Volume 23, Number 9, 1 September 2019, pp. 1017-1023(7). PubMed PMID: 31615610.

26.  Keshavjee S, Amanullah F, Cattamanchi A, Dobos K, Fox G, Gendelman H, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn D, Lewinsohn D, Lin L, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin D, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.  Extinguishing the seedbed of tuberculosis: critical issues for research, diagnosis and treatment of tuberculosis infection. Am J Resp Crit Care Med 2019; 199: 564-571. Accepted for publication.

27.  Loveday M, Reuter A, Furin J, Seddon JA, Cox H. The STREAM Trial: missed opportunities and lessons for future clinical trials. Lancet Infect Dis 2019; 19: 351-353. PMID: 30910428.

28.  Marx FM, Cohen T, Lombard C, Hesseling AC, Dlamini SS, Beyers N, et al. Notification of relapse and other previously treated tuberculosis in the 52 health districts of South Africa. Int J Tuberc Lung Dis. 2019;23(8):891-9. Epub 2019/09/20. doi: 10.5588/ijtld.18.0609. PMID: 31533878.

29.  Meyers T, Samson P, Acosta EP, Moye J, Townley E, Bradford S, Marillo L, Denson K, Hovind L, Thucuma S, Teppler S, Mathiba SR, Masenya M, Hesseling A, Cotton MF, and Krogstad P. Pharmacokinetics and safety of a raltegravir containing regimen in HIV-infected children aged 2 to12 years on rifampicin for tuberculosis.  AIDS 2019. PMID: 31689263.

30.  Mishra H, Reeve BWP, Palmer Z, Caldwell J, Dolby T, Naidoo CC, Jackson JG, Schumacher SG, Denkinger CM, Diacon AH, van Helden PD, Marx FM, Warren RM, Theron G. Xpert Ultra and Xpert MTB/RIF for tuberculosis diagnosis in an HIV-endemic setting with a high burden of previous tuberculosis: a two-cohort diagnostic accuracy study. Lancet Resp Med. Accepted for publication.

31.  Mohiyuddin T, Seddon JA, Thomas L, Lalor M. The changing landscape of childhood tuberculosis in the United Kingdom: a retrospective cohort (2000 to 2015). Ped Infect Dis J 2019; 38: 470-475. PMID: 30256311.

32.  Mohr-Holland EK, Apolisi I, Reuter A, de Azevedo V, Hill JS, Matthee S, Seddon JA, Isaakidis P, Furin J, Triviño-Durán L. Barriers and solutions to finding Rifampicin-Resistant tuberculosis cases in older children and adolescents. Pub Health Action Public Health Action, 2019: 9(4), pp.174-176.

33.  Myburgh H, Peters R, Hurter T, Grobbelaar, CJ, Hoddinott G. Transition to an in-facility electronic TB register: lessons from a South African pilot project. South African Journal of HIV Medicine. Accepted for Publication.

34.  Nahid P, Mase SR, Migliori GB, Sotgiu G, Bothamley GH, Brozek JL, Cattamanchi A, Cegielski JP, Chen L, Daley CL, Dalton TL, Duarte R, Fregonese F, Horsburgh CR, Khan FA, … Schaaf HS, Shah NS, Starke JR, Wilson JW, Wortham JM, Chorba T, and Seaworth B; on behalf of the American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America. Treatment of drug-resistant tuberculosis: an official ATS/CDC/ERS/IDSA clinical practice guideline. Am J Respir Crit Care Med. 2019 Nov 15;200(10):e93-e142. PMID: 31729908. PMCID: PMC6857485

35.  Osman M, Harausz EP, Garcia-Prats, AJ, Schaaf HS, Moore BK, Hicks RM, Achar J, Amanullah F, Barry P, Becerra M, Chiotan DI, Drobac PC, Flood J, Furin J, Gegia M, Isaakidis, P, Mariandyshev, A, Ozere, I, Shah NS, Skrahina A, Yablokova E, Seddon JA, Hesseling AC, Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR TB. (2019). Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis. Emerging infectious diseases, 25(3), 441–450. doi:10.3201/eid2503.180852 PMID: 31729908. PMCID: PMC6857485.

36.  Osman M, Welte A, Dunbar R, Brown R, Hoddinott G, Hesseling AC and Marx FM. 2019. Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa: A pilot study. Int J Infect Dis 85: 57-63. PMID: 31132472.

37.  Purchase SE, Garcia-Prats AJ, De Koker P, Draper H, Seddon JA, Schaaf HS, Hesseling AC. Acceptability of a novel levofloxacin dispersible tablet formulation in young children exposed to multidrug-resistant tuberculosis. Ped Infect Dis J 2019; 38: 608-610. PMID: 30550511.

38.  Radtke KK, Dooley KE, Dodd PJ, Garcia-Prats AJ, McKenna L, Hesseling AC, Savic RM.  Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study. Lancet Child Adolesc Health 2019  Published Online July 16, 2019 http://dx.doi.org/10.1016/S2352-4642(19)30196-8 PMID: 31324596.

39.  Reuter A, Hughes J, Furin J. Challenges and controversies in childhood tuberculosis. Lancet. 2019 Sep 14;394(10202):967-978. PMID: 31526740.

40.   Reid M, Arinaminpathy N, Bloom A, Bloom B, Boehme C, Chaisson R, Chin D, Churchyard G, Cox H, Ditiu L, Dybul M, Farrar J, Fauci A, Fedaku E, Fujiwara P, Hallett T, Hanson C, Harrington M, Herbert N, Hopewell P, Ikeda C, Jamison D, Khan A, Koek I, Krishnan N, Motsoaledi A, Pai M, Raviglione M, Sharman A, Small P, Swaminathan S, Temesgen Z, Vassall A, Venkatesan N, van Weezenbeek K, Yamey G, Agins B, Alexandru S, Andrews J, Beyeler N, Bivol S, Brigden G, Cattamanchi, A, Cazabon D, Crudu V, Daftary A, Dewan P, Doepel L, Eisinger R, Fan V, Fewer S, Furin J, Goldhaber-Fiebert J, Gomez G, Graham S, Gupta D, Kamene M, Khaparde S, Mailu EW, Masini E, McHugh L, Mitchell E, Moon S, Osberg M, Pande T, Prince L, Rade K, Rao R, Remme M, Seddon JA, Selwyn C, Shete P, Stallworthy G, Vesga JF, Vilc V, Goosby E. ‘Building a tuberculosis-free world’:  The Lancet Commission on tuberculosis. Lancet. 2019 Mar 30;393(10178):1331-1384. doi: 10.1016/S0140-6736(19)30024-8. Epub 2019 Mar 20. PMID: 30904263.

41.   Sartoris G, Seddon JA, Rabie H, Nel ED, Schaaf HS. Abdominal tuberculosis in children: challenges, uncertainty and confusion. J Ped Infect Dis Soc 2019. PMID: 31909804.

42.  Schaaf HS, Marais BJ. The Role of Xpert MTB/RIF Ultra in Diagnosing Pulmonary Tuberculosis in Children Am J Respir Crit Care Med. 2019 Aug 6. doi: 10.1164/rccm.201907-1492ED. [Epub ahead of print] PubMed: 31386819.

43.  Schaaf HS. Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach. The Indian Journal of Pediatrics (August 2019) 86(8):717-724; https://doi.org/10.1007/s12098-018-02846-8. PMID: 30656560.

44.  Seddon JA, Whittaker EJ, Kampmann B, Lewinsohn D, Osman M, Hesseling AC, Amadulah F. The evolving research agenda for paediatric tuberculosis infection. Lancet Infect Dis 2019. PMID: 31221543.

45.  Seddon JA. Thwaites GE. Tuberculous meningitis: new tools and new approaches required. Wellcome Open Research

46.  Seeley J, Bond V, Yang B, Floyd S, MacleaodD, Viljoen L, Phiri M, Simuyaba M, Hoddinott G, Shanaube K, Bwalya C, De Villiers BL, Dunbar R, Bock PA, Hayes R, Fidler S; HPTN 071 (PopART) study team. Understanding the time needed to link to care and start ART in seven HPTN 071 (PopART) study communities in Zambia and South Africa. AIDS and Behavior 2019; 23:929-946. PMID: 30415432. PMCID: PMC6458981.

47.  Snow KJ, Cruz AT, Seddon JA, Ferrand RA, Chiang SS, Hughes J, Kampmann B, Graham SM, Dodd PJ, Houben RMGJ, Denholm JT, Sawyer SM, Kranzer K. Adolescent tuberculosis: The missing middle. Lancet Child and Adol Health. [Epub ahead of print] Trans R Soc Trop Med Hyg 2019; 113: S1–S98.

48.   Suryavanshi N, Murrill M, Gupta A, Hughes M, Hesseling A, Kim S, Naini L, Jones L, Smith B, Gupte N, Dawson R, Mave V, Meshram S, Mendoza-Ticona A, Sanchez J, Kumarasamy N, Comins K, Conradie F, Shenje J, Nerette Fontain S, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo U, Ferreira ACG, Okeyo E, Swindells S, Churchyard G, Shah NS; A5300/I2003 Study Team. Willingness to take multidrug-resistant tuberculosis (MDR-TB) preventive therapy among adult and adolescent household contacts of MDR-TB index cases: An International Multi-Site Cross-Sectional Study. Clin Infect Dis. 2019 Mar 28. pii: ciz254. doi: 10.1093/cid/ciz254. [Epub ahead of print] PMID: 30919881.

49.  Thomas R, Friebel R, Barker K, Mwenge L, Kanema S, Vanqa N, Harper A, Bell-Mandla N, Smith PC, Floyd S, Bock P, Ayles H, Fidler S, Hayes R, Hauck K; HPTN 071 (PopART) Study Team. Work and home productivity of people living with HIV in Zambia and South Africa. AIDS. 2019 May 1;33(6):1063-1071. PMID: 30946160.

50.  van der Heijden YF, Hughes J, Dowdy DW,  Streicher E, Chihota V, Jacobson KR, Warren R, Theron G. Overcoming limitations of tuberculosis information systems: researcher and clinician perspectives. Public Health Action, Volume 9, Number 3, 1 September 2019, pp. 120-127(8). PMID: 31803584. PMCID: PMC6827492.

51.  Vaneesa Vanker, Polite M Nduru , Whitney Barnett, Felix S Dube , Peter D Sly, Robert P Gie , Mark P Nicol , Heather J Zar. Indoor air pollution and tobacco smoke exposure: impact on nasopharyngeal bacterial carriage in mothers and infants in an African birth cohort study. ERJ Open Res. 2019;5(1):00052-2018. Published 2019 Feb 4. doi:10.1183/23120541.00052-2018. PMID: 30740462.

52.  Wademan DT, Busakwe L, Nicholson TJ, van der Zalm M, Palmer M, Workman J, Turkova, A, Crook, A.M, Thomason, MJ, Gibb, DM, Seeley, J, Hesseling A, and Hoddinott G on behalf of the SHINE trial team. Acceptability of a first-line antituberculosis formulation for children: qualitative data from the SHINE trial. The International Journal of Tuberculosis and Lung Disease, 23(12), pp.1263-1268.

53.  Walters E, van der Zalm MM, Demers AM, Whitelaw A, Palmer M, Bosch C, Draper HR, Schaaf HS, Goussard P, Lombard CJ, Gie RP, Hesseling AC. Specimen Pooling as a Diagnostic Strategy for Microbiologic Confirmation in Children with Intrathoracic Tuberculosis. Pediatr Infect Dis J. 2019 Jun;38(6):e128-e131. PMID: 30418355.

54.  Whittaker EJ, Lopez E, Broderick C, Seddon JA. Examining the complex relationship between tuberculosis and other infectious diseases in children: A review. Frontiers in pediatrics, 7, p.233. PMID: 31294001 PMCID: PMC6603259,

55.  Zimri K, Casper R., Hoddinott G, Schaaf HS, Garcia-Prats AJ, Rose PC, Hesseling AC, and Viljoen L. 2019. A novel approach for eliciting adolescent MDR-TB treatment tolerability: qualitative data from South Africa.. Int J Tuberc Lung Dis. 2020 Jan 1;24(1):43-47. doi: 10.5588/ijtld.19.0207. PMID: 32005306.

Book Chapters

1. Whittaker E, Welch S, Cohen J, Seddon JA. Tuberculosis in Children and Adolescents. In: Tuberculosis in Clinical Practice. Ed. Onn Min Kon. Springer.