The University of Stellenbosch

Publications during 2018

During 2018, the Desmond Tutu TB Centre continued to contribute to field of academic knowledge. Researchers from the Centre published 72 articles in academic and peer reviewed journals:

  1. Allwood BW, Maarman GJ, Kyriakakis CG, Doubell, AF. Post-pulmonary tuberculosis complications in South Africa and a potential link with pulmonary hypertension: Premise for clinical and scientific investigations. S Afr Med J. 2018 Jun. 26;108(7):12339. doi: 10.7196/SAMJ.2018.v108i7.13359. PubMed PMID: 30004336.
  2. Basu-Roy R, Whittaker E, Seddon JA, Kampmann B. Tuberculosis susceptibility and protection in children. Lancet Infect Dis. 2018 Oct 12. pii: S1473-3099(18)30157-9. doi: 10.1016/S1473-3099(18)30157-9. Epub ahead of print. PubMed PMID: 30322790.
  3. Bock P, Fatti G, Ford N, Jennings K, Kruger J, Gunst C, Louis F, Grobbelaar N, Shanaube K, Floyd S, Grimwood A, Hayes R, Ayles H, Fidler S, Beyers N; HPTN 071 (PopART) trial team. Attrition when providing antiretroviral treatment at CD4 counts >500cells/muL at three government clinics included in the HPTN 071 (PopART) trial in South Africa. PLoS One. 2018 Apr 19;13(4):e0195127. doi: 10.1371/journal.pone.0195127. PubMed PMID: 29663952.
  4. Bock P, Jennings K, Vermaak R, Cox H, Meintjes G, Fatti G, Kruger J, De Azevedo V, Maschilla L, Louis F, Gunst C, Grobbelaar N, Dunbar R, Limbada M, Floyd S, Grimwood A, Ayles H, Hayes R, Fidler S, Beyers N. Incidence of Tuberculosis among HIV-positive individuals initiating antiretroviral treatment at higher CD4 counts in the HPTN 071 (PopART) trial in South Africa. J Acquir Immune Defic Syndr. 2018 Jan 1;77(1):93-101. doi: 10.1097/QAI.0000000000001560. PubMed PMID: 29016524.
  5. Bond, V, Ngwenya F, Thomas A, Simuyaba M, Hoddinott G, Fidler S, Hayes R, Ayles H, Seeley, J; HPTN 071 (PopART) study team. Spinning plates: livelihood mobility, household responsibility and anti-retroviral treatment in an urban Zambian community during the HPTN 071 (PopART) study. J Int AIDS Soc. 2018 Jul;21 Suppl 4:e25117. doi.org/10.1002/jia2.25117. PubMed PMID: 30027643.
  6. Bond V, Nomsenge S, Mwamba M, Ziba D, Birch A, Mubekapi-Musadaidzwa C, Vanqa N, Viljoen L, Pliakas T, Ayles H, Hargreaves J, Hoddinott G, Stangl A, Seeley J; HPTN 071 (PopART) study team. “Being seen” at the clinic: Zambian and South African health worker reflections on the relationship between health facility spatial organisation and items and HIV stigma in 21 health facilities, the HPTN 071 (PopART) study. Health Place. 2018 Dec 7. pii: S1353-8292(18)30608-7. doi: 10.1016/j.healthplace.2018.11.006. [Epub ahead of print]. PubMed PMID: 30528346.
  7. Bond V, Ngwenya F, Murray E, Ngwenya N, Viljoen L, Gumede D, Bwalya C, Mantantana J, Hoddinott G, Dodd PJ, Ayles H, Simwinga M, Wallman S, Seeley J. Value and Limitations of Broad Brush Surveys Used in Community-Randomized Trials in Southern Africa. Qual Health Res. 2018 Dec 17:1049732318809940. doi: 10.1177/1049732318809940. [Epub ahead of print]. PubMed PMID: 30556470.
  8. Bradley J, Floyd S, Piwowar-Manning E, Laeyendecker O, Young A, Bell-Mandla N, Bwalya J, Bock P, Fidler S, Ayles H, Hayes, RJ; HPTN 071(PopART) Study Team. Sexually transmitted bedfellows: exquisite association between HIV and Herpes Simplex Virus Type 2 in 21 Communities in Southern Africa in the HIV Prevention Trials Network 071 (PopART) study. J Infect Dis. 2018 Jul 2;218(3):443-452. doi: 10.1093/infdis/jiy178. PubMed PMID: 29659909.
  9. Byamungu LN, du Preez K, Walters E, Nachega JB, Schaaf HS. Timing of HIV diagnosis in children with tuberculosis managed at a referral hospital in Cape Town, South Africa. Int J Tuberc Lung Dis. 2018 May 1;22(5):488-495. doi: 10.5588/ijtld.17.0613. PubMed PMID: 29663952.
  10. Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, Mave V, van der Zalm M, Palmer M, Kapasa M, Bhavani PK, Balaji S, Raichur PA, Demers AM, Hoddinott G, Owen-Powell E, Kinikar A, Musoke P, Mulenga V, Aarnoutse R, McIlleron H, Hesseling A, Crook AM, Cotton M, Gibb DM; SHINE trial team. Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial. Trials. 2018 Apr 19;19(1):237. doi: 10.1186/s13063-018-2608-5. PubMed PMID: 29673395.
  11. Cranmer LM, Draper HR, Mandalakas AM, Kim S, McSherry G, Krezinski E, Coetzee J, Mitchell C, Nachman S, van der Linde M, Cotton MF, Hesseling AC; IMPAACT P1041 Team. High incidence of tuberculosis infection in HIV-exposed children exiting an Isoniazid preventive therapy trial. Pediatr Infect Dis J. 2018 Oct;37(10):e254-e256. doi: 10.1097/INF.0000000000001946. PubMed PMID: 29462104.
  12. Cruz AT, Garcia-Prats AJ, Furin J, Seddon JA. Treatment of Multidrug-Resistant Tuberculosis Infection in Children.  Pediatr Infect Dis J. 2018 Oct;37(10):1061-1064. doi: 10.1097/INF.0000000000002135. No abstract   PubMed PMID: 30216296.
  13. Denti P, Garcia-Prats AJ, Draper HR, Wiesner L, Winckler J, Thee S, Dooley KE, Savic RM, McIlleron HM, Schaaf HS, Hesseling AC. Levofloxacin population pharmacokinetics in South African children treated for multidrug-resistant tuberculosis. Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01521-17. doi: 10.1128/AAC.01521-17. PubMed PMID: 29133560.
  14. Dodd PJ, Yuen CM, Becerra MC, Revill P, Jenkins HE, Seddon JA. Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study. Lancet Glob Health. 2018 Dec;6(12):e1329-e1338. doi: 10.1016/S2214-109X(18)30401-7. PubMed PMID: 30266570.
  15. Donald PR, Diacon AH, Lange C, Demers AM, von Groote-Biddlingmeier F, Nardell E. Droplets, dust and guinea pigs: an historical review of tuberculosis transmission research. 1878–1940. Int J Tuberc Lung Dis. 2018 Sep 1;22(9):972-982. doi: 10.5588/ijtld.18.0173. PubMed PMID: 30092861.
  16. du Preez K, Schaaf HS, Dunbar R, Walters E, Swartz A, Solomons R, Hesseling AC. Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children. BMC Public Health. 2018 Mar 23;18(1):397. doi: 10.1186/s12889-018-5252-9. PubMed PMID: 29566651.
  17. du Preez K, du Plessis L, O’Connell N, Hesseling AC. Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa. The International Journal of Tuberculosis and Lung Disease. 2018 Sep 1;22(9):1037-1043. doi: 10.5588/ijtld.17.0893. PubMed PMID: 30092869.
  18. Floyd S, Schaap A, Shanaube K, Macleod D, Phiri M, Griffith S, Bock P, Beyers N, Fidler S, Hayes R, on behalf of the HPTN 071 (PopART) study team. Towards 90-90: Findings after two years of the HPTN071 (PopART) universal testing-and-treatment intervention in Zambia. PLoS One. 2018; 13(8): e0197904. PubMed PMID: 30096139.
  19. Fregonese F, Ahuja SD, Akkerman OW, Arakaki-Sanchez D, Ayakaka I, Baghaei P, Bang D, Bastos M, Benedetti A, Bonnet M, Cattamanchi A, Cegielski P, Chien JY, Cox H, Dedicoat M, Erkens C, Escalante P, Falzon D, Garcia-Prats AJ, Gegia M, Gillespie SH, Glynn JR, Goldberg S, Griffith D, Jacobson KR, Johnston JC, Jones-López EC, Khan A, Koh WJ, Kritski A, Lan ZY, Lee JH, Li PZ, Maciel EL, Galliez RM, Merle CSC, Munang M, Narendran G, Nguyen VN, Nunn A, Ohkado A, Park JS, Phillips PPJ, Ponnuraja C, Reves R, Romanowski K, Seung K, Schaaf HS, Skrahina A, Soolingen DV, Tabarsi P, Trajman A, Trieu L, Banurekha VV, Viiklepp P, Wang JY, Yoshiyama T, Menzies D. Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis. Lancet Respir Med. 2018 Apr;6(4):265-275. doi: 10.1016/S2213-2600(18)30078-X. PubMed PMID: 29595509.
  20. Frigati L, Bekker A, Stroebele S, Goussard P, and Schaaf HS. Culture-Confirmed Tuberculosis in South African Infants Younger Than 3 Months of Age: Clinical Presentation and Management of Respiratory Complications. The Pediatric infectious disease journal. 2018 Aug 27. doi: 10.1097/INF.0000000000002163. PubMed PMID: 30153235.
  21. Furin J, Tommasi M, Garcia-Prats AJ. Drug-resistant tuberculosis: will grand promises fail children and adolescents?  Lancet Child Adolesc Health. 2018 Apr;2(4):237-238. doi: 10.1016/S2352-4642(18)30068-3. Epub 2018 Mar 13. No abstract availa PubMed PMID: 30169295
  22. Garcia-Prats AJ, Draper HR, Finlayson H, Winckler J, Burger A, Fourie B, Thee S, Hesseling AC, Schaaf HS. Clinical and cardiac safety of long-term levofloxacin in children treated for multidrug-resistant tuberculosis. Clin Infect Dis. 2018 Nov 13;67(11):1777-1780. doi: 10.1093/cid/ciy416. PubMed PMID: 29788331.
  23. Garcia-Prats AJ, Rose PC, Draper HR, Seddon JA, Norman J, McIlleron HM, Hesseling AC, Schaaf HS. Effect of co-administration of Lidocaine on the pain and pharmacokinetics of intramuscular Amikacin in children with multidrug-resistant tuberculosis: a randomized crossover trial. Pediatr Infect Dis J. 2018 Dec;37(12):1199-1203. doi: 10.1097/INF.0000000000001983. PubMed PMID: 29561515.
  24. Garcia-Prats AJ, Svensson EM, Weld ED, Schaaf HS, Hesseling, AC. Current status of pharmacokinetic and safety studies of multidrug-resistant tuberculosis treatment in children. Int J Tuberc Lung Dis. 2018 May 1;22(5):15-23. doi: 10.5588/ijtld.17.0355. PubMed PMID: 29665949.
  25. García-Basteiro AL, Schaaf HS, Diel R, Migliori GB. Adolescents and young adults: a neglected population group for tuberculosis surveillance. Eur Respir J. 2018 Feb 21;51(2). pii: 1800176. doi: 10.1183/13993003.00176-2018. PubMed PMID: 2946721.1.
  26. Goussard P, Gie RP, Janson J. Lethal fibrosing mediastinitis in a child possibly due to Mycobacterium tuberculosis. PMID: 29635837 Pediatr Pulmonol. 2018 Jun;53(6):E18-E20. doi: 10.1002/ppul.24012. Epub 2018 Apr 10. DOI: 10.1002/ppul.24012.
  27. Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Méndez-Echevarría A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC; Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB. Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis. PLoS Med. 2018 Jul 11;15(7):e1002591. doi: 10.1371/journal.pmed.1002591. PubMed PMID: 29995958.
  28. Hargreaves JR, Krishnaratne S, Mathema H, Lilleston PS, Sievwright K, Mandla N, Mainga T, Vermaak R, Piwowar-Manning E, Schaap A, Donnell D, Ayles H, Hayes RJ, Hoddinott G, Bond V, Stangl A; HPTN 071 (PopART) Study Team. Individual and community-level risk factors for HIV stigma in 21 Zambian and South African communities: analysis of data from the HPTN071 (PopART) study. AIDS. 2018 Mar 27;32(6):783-793. doi: 10.1097/QAD.0000000000001757. PubMed PMID: 29369164.
  29. Hirsch-Moverman Y, Mantell JE, Lebelo L, Wynn C, Hesseling AC, Howard AA, Nachman S, Frederix K, Maama LB, El-Sadr WM. Tuberculosis preventive treatment preferences among care givers of children in Lesotho: a pilot study. Int J Tuberc Lung Dis. 2018 Aug 1;22(8):858-862. doi: 10.5588/ijtld.17.0809. PubMed PMID: 29991393.
  30. Hoddinott G, Hesseling AC. Sociobehavioural science is needed to understand the impact of paediatric MDR-TB treatment on children and their families. Int J Tuberc Lung Dis. 2018 Jan 1;22(1):4. doi: 10.5588/ijtld.17.0814. PubMed PMID: 29297419.
  31. Hoddinott G, Myburgh H, de Villiers L, Ndubani R, Mantantana J, Thomas A, Mbewe M, Ayles H, Bock P, Seeley J, Shanaube K, Hargreaves J, Bond V, Reynolds L; HPTN 071 (PopART) Study Team. Households, fluidity, and HIV service delivery in Zambia and South Africa – an exploratory analysis of longitudinal qualitative data from the HPTN 071 (PopART) trial. J Int AIDS Soc. 2018 Jul;21 Suppl 4:e25135. doi: 10.1002/jia2.25135. PubMed PMID: 30027687.
  32. Hoddinott G, Staples S, Brown R, Simwinga M, Mubekapi-Musadaidzwa C, Hesseling AC, Hendricks G, De Koker P, McKenna L. Community engagement for paediatric MDR-TB clinical trials: principles to support ethical trial implementation. Int J Tuberc Lung Dis.2018 May 1;22(5):40-45. doi: 10.5588/ijtld.17.0356. PubMed PMID: 29665952.
  33. Innes S, van der Laan L, Anderson PL, Cotton M, Denti P. Can we improve Stavudine’s safety profile in children? Pharmacokinetics of intracellular Stavudine Triphosphate with reduced dosing. Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e00761-18. doi: 10.1128/AAC.00761-18. PubMed PMID: 30104267.
  34. Jacobs C, Goussard P, Gie RP. Mycobacterium tuberculosis, a cause of necrotising pneumonia in childhood: a case series. Int J Tuberc Lung Dis. 2018 Jun 1;22 (6):614-616. doi: 10.5588/ijtld.17.0570. Epub 2018 Mar 22. PMID: 29566781 DOI: 10.5588/ijtld.17.0570
  35. Kampmann B, Seddon JA, Paton J, Nademi Z, Keane D, Williams B, Williams A, Liebeschutz S, Riddell A8, Bernatoniene J, Patel S, Martinez N, McMaster P, Basu-Roy R, Welch SB. Evaluating UK national guidance for screening of children for tuberculosis. A prospective multicenter study. Am J Respir Crit Care Med. 2018 Apr 15;197(8):1058-1064. doi: 10.1164/rccm.201707-1487OC. PubMed PMID: 29190430.
  36. Kay A, Garcia-Prats AJ, Mandalakas A M. HIV-associated pediatric tuberculosis: prevention, diagnosis and treatment. Curr Opin HIV AIDS. 2018 Nov;13(6):501-506. doi: 10.1097/COH.0000000000000500. PubMed PMID: 30286040.
  37. Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P. Moving toward tuberculosis elimination: critical issues for research in diagnostics and therapeutics for tuberculosis infection. Am J Respir Crit Care Med. 2018 Oct 18. doi: 10.1164/rccm.201806-1053PP. [Epub ahead of print] PubMed PMID: 30335466.
  38. Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A. Transmission of drug-resistant tuberculosis in HIV-endemic settings. Lancet Infect Dis. 2018 Dec 13. pii: S1473-3099(18)30537-1. doi: 10.1016/S1473-3099(18)30537-1. [Epub ahead of print] Review. PubMed PMID: 30554996.
  39. Kim S, Seddon JA, Garcia-Prats AJ, Montepiedra G. Statistical considerations for pediatric multidrug-resistant tuberculosis efficacy trials. Int J Tuberc Lung Dis. 2018 May 1;22(5):34-39. doi: 10.5588/ijtld.17.0358. PubMed PMID: 29665951.
  40. Liu C, Lyon CJ, Bu Y, Deng Z, Walters E, Li Y, Zhang L, Hesseling AC, Graviss EA, Hu Y. Clinical evaluation of a blood assay to diagnose Paucibacillary tuberculosis via bacterial antigens. Clin Chem. 2018 May;64(5):791-800. doi: 10.1373/clinchem.2017.273698. PubMed PMID: 29348166.
  41. Maarman GJ. Pulmonary arterial hypertension and the potential roles of metallothioneins: A focused review. Life Sci. 2018 Dec 1;214:77-83. doi: 10.1016/j.lfs.2018.10.039. Epub 2018 Oct 22. PubMed PMID: 30355531
  42. Mann TN, Schaaf HS, Dunn RN, Dix-Peek S, du Preez K, Lamberts RP, du Toit J, Davis JH. Child and adult spinal tuberculosis at tertiary hospitals in the Western Cape, South Africa: 4-year burden and trend. Epidemiol Infect. 2018 Dec;146(16):2107-2115. doi: 10.1017/S0950268818002649. Epub 2018 Sep 28. PubMed PMID: 30264687.
  43. Marx FM, Yaesoubi R, Menzies NA, Salomon JA, Bilinski A, Beyers N, Cohen T. Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study. Lancet Glob Health. 2018 Apr;6(4):e426-e435. doi: 10.1016/S2214-109X(18)30022-6. PubMed PMID: 29472018.
  44. Meehan SA, Sloot R, Draper HR, Naidoo P, Burger R, Beyers N. Factors associated with linkage to HIV care and TB treatment at community-based HIV testing services in Cape Town, South Africa. PLoS One. 2018 Apr 2;13(4):e0195208. doi: 10.1371/journal.pone.0195208. eCollection 2018. PubMed PMID: 29608616.
  45. Mohiyuddin T, Seddon JA, Thomas HL, Lalor MK. The changing landscape of childhood Tuberculosis in the United Kingdom: A retrospective cohort (2000 to 2015). Pediatr Infect Dis J. 2018 Sep 25. doi: 10.1097/INF.0000000000002200. PubMed PMID: 30256311.
  46. Myburgh H, Calitz E, Railton JP, Maluleke C, Mashao E, Ketelo P, Jobson G, Grobbelaar CJ, Struthers HE, Peters RPH. Breaking down barriers to tell: A mixed methods study of health worker involvement in disclosing to children that they are living with HIV in rural South Africa. J Assoc Nurses AIDS Care. 2018 Nov – Dec;29(6):902-913. doi: 10.1016/j.jana.2018.04.009. Epub 2018 Apr 25. PubMed PMID: 29784521.
  47. Nemes E, Hesseling AC, Tameris M, Mauff K, Downing K, Mulenga H, Rose P, van der Zalm M, Mbaba S, Van As D, Hanekom WA, Walzl G, Scriba TJ, McShane H, Hatherill M; MVA029 Study Team. Safety and immunogenicity of newborn MVA85A vaccination and selective, delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected mothers: a phase 2 randomized, controlled trial. Clin Infect Dis. 2018 Feb 1;66(4):554-563. doi: 10.1093/cid/cix834. PubMed PMID: 29028973.
  48. Obihara NJ, Walters E, Lawrenson J, Garcia-Prats AJ, Hesseling AC, Schaaf HS. Tuberculous Pericardial Effusions in Children. J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):346-349. doi: 10.1093/jpids/pix087. PubMed PMID: 29096017
  49. Opollo VS, Wu X, Hughes MD, Swindells S, Gupta, A, Hesseling A, Churchyard G, Kim S, Lando R, Dawson R, Mave V, Mendoza A, Gonzales P, Kumarasamy N, von Groote-Bidlingmaier F, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash, A, Nedsuwan S, Mohapi L, Mngqibisa R, Garcia Ferreira AC, Okeyo E, Naini L, Jones L, Smith B, Shah NS. HIV testing uptake among the household contacts of multidrug-resistant tuberculosis index cases in eight countries. Int J Tuberc Lung Dis. 2018 Dec 1;22(12):1443-1449. doi: 10.5588/ijtld.18.0108. PubMed PMID: 30606316.
  50. Purchase SE, Garcia-Prats AJ, De Koker P, Draper HR, Osman M, Seddon JA, Schaaf HS, Hesseling AC. Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-Resistant Tuberculosis. Pediatr Infect Dis J. 2018 Dec 13. doi: 10.1097/INF.0000000000002268. [Epub ahead of print] PubMed PMID: 30550511.
  51. Rosser A, Marx FM, Pareek M. Recurrent tuberculosis in the pre-elimination era. Int J Tuberc Lung Dis. 2018 Feb 1;22(2):139-150. doi: 10.5588/ijtld.17.0590. PubMed PMID: 29506610.
  52. Basu-Roy R, Whittaker, E, Seddon JA, Kampmann B. Tuberculosis susceptibility and protection in children. Lancet Infect Dis. 2018 Oct 12. pii: S1473-3099(18)30157-9. doi: 10.1016/S1473-3099(18)30157-9. PubMed PMID: 30322790.
  53. Sabapathy K, Mulubwa C, Mathema H, Mubekapi-Musadaidzwa C, Schaap A, Hoddinott G, Hargreaves J, Floyd S, Ayles H, Hayes R; HPTN 071 (PopART) Study Team. Is home‐based HIV testing universally acceptable? Findings from a case–control study nested within the HPTN 071 (Pop ART) trial. Trop Med Int Health. 2018 Jun;23(6):678-690. doi: 10.1111/tmi.13055. Epub 2018 Apr 16. PubMed PMID: 29608231.
  54. Schaaf HS, Garcia-Prats AJ, McKenna L, Seddon JA. Challenges of using new and repurposed drugs for the treatment of multidrug-resistant tuberculosis in children. Expert Rev Clin Pharmacol. 2018 Mar;11(3):233-244. doi: 10.1080/17512433.2018.1421067. PubMed PMID: 29280409.
  55. Seddon JA, Weld ED, Schaaf HS, Garcia-Prats AJ, Kim S, Hesseling AC. Conducting efficacy trials in children with MDR-TB: what is the rationale and how should they be done? The Int J Tuberc Lung Dis. 2018 May 1;22(5):24-33. doi: 10.5588/ijtld.17.0359. PubMed PMID: 29665950.
  56. Seddon JA, Garcia-Prats AJ, Purchase SE, Osman M, Demers AM, Hoddinott G, Crook AM, Owen-Powell E, Thomason MJ, Turkova A, Gibb DM, Fairlie L, Martinson N, Schaaf HS, Hesseling AC. Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis: study protocol for a phase III cluster randomised controlled trial (TB-CHAMP). Trials. 2018 Dec 20;19(1):693. doi: 10.1186/s13063-018-3070-0. PubMed PMID: 30572905; PubMed Central PMCID: PMC6302301.
  57. Seddon JA, Schaaf HS, Marais BJ, McKenna L, Garcia-Prats AJ, Hesseling AC, Hughes J, Howell P, Detjen A, Amanullah F, Singh U, Master I, Perez-Velez CM, Misra N, Becerra MC, Furin. Time to act on injectable-free regimens for children with multidrug-resistant tuberculosis. Lancet Respir Med. 2018 Sep;6(9):662-664. doi: 10.1016/S2213-2600(18)30329-1. PubMed PMID: 30191832
  58. Seddon JA, Chiang SS, Esmail H, Coussens AK. The Wonder Years: What Can Primary School Children Teach Us About Immunity to Mycobacterium tuberculosis? Front Immunol. 2018 Dec 13;9:2946. doi: 10.3389/fimmu.2018.02946. eCollection 2018. PubMed PMID: 30619306.
  59. Seeley J, Bond V, Yang B, Floyd S, MacLeod D, Viljoen L, Phiri M, Simuyaba M, Hoddinott G, Shanaube K, Bwalya C, de Villiers L, Jennings K, Mwanza M, Schaap A, Dunbar R, Sabapathy K, Ayles H, Bock P, Hayes R, Fidler S; HPTN 071 (PopART) study team. Understanding the Time Needed to Link to Care and Start ART in Seven HPTN 071 (PopART) Study Communities in Zambia and South Africa. AIDS Behav. 2018 Nov 10. doi: 10.1007/s10461-018-2335-7. [Epub ahead of print]. PubMed PMID: 30415432.
  60. Sloot R, Maarman GJ, Osman M, Marx F. On Behalf Of The Desmond Tutu Tb Centre-Working Group Data Analysis And Modelling FM. Variation in HIV prevalence and the population-level effects of antiretroviral therapy in reducing tuberculosis incidence in South Africa. S Afr Med J. 2018 Jul 25;108(8):12370. doi: 10.7196/SAMJ.2018.v108i8.13394. PubMed PMID: 30182871.
  61. Svensson EM, du Bois J, Kitshoff R, de Jager VR, Wiesner L, Norman J, Nachman S, Smith B, Diacon AH, Hesseling AC, Garcia-Prats AJ. Relative bioavailability of bedaquiline tablets suspended in water: implications for dosing in children. Br J Clin Pharmacol. 2018 Jun 27. doi: 10.1111/bcp.13696. [Epub ahead of print] PubMed PMID: 29952141.
  62. Swindells S, Gupta A, Kim S, Hughes MD, Sanchez J, Mave V, Dawson R, Kumarasamy N, Comins K, Smith B, Rustomjee R, Naini L, Shah NS, Hesseling A, Churchyard G. Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003). Int J Tuberc Lung Dis. 2018 Sep 1;22(9):1016-1022. doi: 10.5588/ijtld.18.0163. PubMed PMID: 30092866; PubMed Central PMCID: PMC6104641.
  63. Thuboy B, Kellermann T, Castel S, Norman J, Joubert A, Garcia-Prats AJ, Hesseling AC, Wiesner L. The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction. Biomed Chromatogr. 2018 May 3:e4269. doi: 10.1002/bmc.4269. PubMed PMID: 29726023.
  64. Vanker A, van der Laan LE, Garcia-Prats AJ, Schaaf HS, Tikiso T, Wiesner L, de Kock M, Winckler J, Norman J, McIlleron H, Denti P, Hesseling AC. Pharmacokinetics and drug-drug interactions of Lopinavir-Ritonavir administered with first- and second-line antituberculosis drugs in HIV-Infected children treated for multidrug-resistant tuberculosis. Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00420-17. doi: 10.1128/AAC.00420-17. PubMed PMID: 29133558.
  65. Van Elsland SL, Van Dongen SI, Bosmans JE, Schaaf HS, Van Toorn R, Van Furth AM. Cost-effectiveness of home-based vs. in-hospital treatment of paediatric tuberculous meningitis. Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1188-1195. doi: 10.5588/ijtld.18.0236. PubMed PMID: 30236187.
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Other Publications

  1. Schaaf HS, Marais BJ, Carvalho I, Seddon JA. Challenges in childhood tuberculosis. In: ERS Monograph: Tuberculosis. Eds. Migliori GB, Bothamley G, Duarte R, Rendon A. European Respiratory Society, Sheffield, UK. 2018:234-262 .
  2. Statement on injectable-free regimens for children under the age of 12 years with rifampicin-resistant tuberculosis  Download PDF
  3. Research Priorities for Paediatric Tuberculosis. World Health Organization. Download PDF
  4. Roadmap towards ending TB in children and adolescents. World Health Organization Download PDF
  5. Best Practices in Child and Adolescent TB Care. World Health Organization Download PDF