BENEFIT Kids | Formulation Development
Improving the availability of child-friendly formulations of 2nd-line TB drugs
Led by TB Alliance and in partnership with Stellenbosch University, the BENEFIT Kids project is working closely with generic manufacturers to accelerate progress and ensure the development of novel or optimised formulations of two key drugs, moxifloxacin and linezolid, to ensure that formulations are child-friendly and palatable. As part of this work, a study of the best tasting formulation blend of these drugs (ChilPref_ML) was successfully completed in healthy child volunteers in South Africa in 2022. The results, to be disseminated in 2023, have informed the taste selection of these new formulations. We will continue to build on this work and undertake more field work on optimal and practical delivery methods of TB medications to children.
BENEFIT Kids: The ChilPref ML Study
Representative procedure for preparation of compounded BDQ syrup suspension from tablets
This video (courtesy TB Alliance) shows a representative procedure for preparation of compounded BDQ syrup suspension. This approach can make pills easier for patients to take.
Downloadable Guides:
- DELAMANID: Use of delamanid in children and adolescents with multidrug- and rifampicin-resistant tuberculosis - Information note
- BEDAQUILINE - Use of bedaquiline in children and adolescents with multidrug- and rifampicin-resistant tuberculosis - Information note
Publications:
- Paediatric formulations for the treatment of drug resistant TB: closing the gaps.
- Stable sugar and sugar-free suspensions of pretomanid.
- Sugar and sugar-free liquid formulations of delamanid for patients with rifampicin-resistant TB.
- Extemporaneously compounded liquid formulations of clofazimine.
- Stable, compounded bedaquiline suspensions to support practical implementation of pediatric dosing in the field.
